DESIGN EXPERT SUPPORTED FORMULATION DEVELOPMENT, MATHEMATICAL OPTIMIZATION AND PREDICTABILITY STUDY OF FLOATING TABLETS OF BISOPROLOL FUMARATE

Objective: Focus of the study was to formulate Design expert Software assisted floating tablet Bisoprolol Fumarate. Fumarate is a Beta adrenergic blocking agent, used treat cardiac diseases favorable characters be formulated as sustained release Gastro retentive tablets.
 Methods: Floating Tablets were prepared by using polymers such Polyox N 12 K and Carbapol 940 P. Formulations direct compression method evaluated for various parameters like Hradness, thickness, weight variations, lag time Total time,% drug Stability Study etc.
 Results: FTIR spectroscopic indicates no drug-excipients interaction in formulations. Hardness or crushing strength tablets all formulation found between 5.8 6.5 kg/cm2. batches range 1.18±2.0 2.43±1.6 (minutes). All other are within an acceptable range. The polymer Carbopol P had significant negative effect on times. In vitro dissolution profiles optimized A3 sustain 99.25 % up h with 1.45 min; Designed stable after study. Optimization carried out 32 factorial designs fabricate formulations.
 Conclusion: It can conclude that reproducible results this developed easily scale up. Furthermore designed will very effective controlling blood pressure.